Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides

[Image: see text] Self-adjuvanting vaccines, wherein an antigenic peptide is covalently bound to an immunostimulating agent, have been shown to be promising tools for immunotherapy. Synthetic Toll-like receptor (TLR) ligands are ideal adjuvants for covalent linking to peptides or proteins. We here i...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Reintjens, Niels R. M., Tondini, Elena, de Jong, Ana R., Meeuwenoord, Nico J., Chiodo, Fabrizio, Peterse, Evert, Overkleeft, Herman S., Filippov, Dmitri V., van der Marel, Gijsbert A., Ossendorp, Ferry, Codée, Jeroen D. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586330/
https://ncbi.nlm.nih.gov/pubmed/32960056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00851
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