Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule

Aiming to increase the potency of synthetic long peptide (SLP)-based cancer vaccines, the Toll-like receptor 2 (TLR2) ligand Pam(3)CSK(4) was conjugated in a chemically defined fashion to SLPs harbouring both cytotoxic T lymphocyte (CTL) and T helper epitopes. We recently showed that these SLP-conju...

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Publié dans:Oncoimmunology
Auteurs principaux: Zom, Gijs G, Filippov, Dmitri V, van der Marel, Gijsbert A, Overkleeft, Hermen S, Melief, Cornelis J, Ossendorp, Ferry
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292239/
https://ncbi.nlm.nih.gov/pubmed/25610736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.947892
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