Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides

[Image: see text] Self-adjuvanting vaccines, wherein an antigenic peptide is covalently bound to an immunostimulating agent, have been shown to be promising tools for immunotherapy. Synthetic Toll-like receptor (TLR) ligands are ideal adjuvants for covalent linking to peptides or proteins. We here i...

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Publicat a:J Med Chem
Autors principals: Reintjens, Niels R. M., Tondini, Elena, de Jong, Ana R., Meeuwenoord, Nico J., Chiodo, Fabrizio, Peterse, Evert, Overkleeft, Herman S., Filippov, Dmitri V., van der Marel, Gijsbert A., Ossendorp, Ferry, Codée, Jeroen D. C.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586330/
https://ncbi.nlm.nih.gov/pubmed/32960056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00851
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