Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure

General control nonderepressible 5 (GCN5, also known as Kat2a) and p300/CBP-associated factor (PCAF, also known as Kat2b) are two homologous acetyltransferases. Both proteins share similar domain architecture consisting of a PCAF N-terminal (PCAF_N) domain, acetyltransferase domain, and a bromodomai...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Toma-Fukai, Sachiko, Hibi, Ryota, Naganuma, Takao, Sakai, Mashito, Saijo, Shinya, Shimizu, Nobutaka, Matsumoto, Michihiro, Shimizu, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586209/
https://ncbi.nlm.nih.gov/pubmed/32820047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013431
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