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Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states. GTPases are deactivated by GTPase-activating pr...

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Publicat a:Molecules
Autors principals: Toma-Fukai, Sachiko, Shimizu, Toshiyuki
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767298/
https://ncbi.nlm.nih.gov/pubmed/31514408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24183308
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