Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding

Small GTPases are molecular switches that have critical biological roles and are controlled by GTPase-activating proteins and guanine nucleotide exchange factors (GEFs). The smg GDP dissociation stimulator (SmgGDS) protein functions as a GEF for the RhoA and RhoC small GTPases. SmgGDS has various re...

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Vydáno v:J Biol Chem
Hlavní autoři: Shimizu, Hikaru, Toma-Fukai, Sachiko, Saijo, Shinya, Shimizu, Nobutaka, Kontani, Kenji, Katada, Toshiaki, Shimizu, Toshiyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555202/
https://ncbi.nlm.nih.gov/pubmed/28630045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792556
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