Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

Adult T-cell leukemia (ATL) is an aggressive T-cell lymphoproliferative malignancy of regulatory T lymphocytes (Tregs), caused by human T-cell lymphotropic virus 1 (HTLV-1). Interleukin 2 receptor alpha (IL-2Rα) is expressed in the leukemic cells of smoldering/chronic ATL patients, leading to consti...

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Detaylı Bibliyografya
Yayımlandı:Transl Oncol
Asıl Yazarlar: Daenthanasanmak, Anusara, Lin, Yuquan, Zhang, Meili, Bryant, Bonita R., Petrus, Michael N., Bamford, Richard N., Thomas, Craig J., Miljkovic, Milos D., Conlon, Kevin C., Waldmann, Thomas A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2020
Konular:
Original article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585144/
https://ncbi.nlm.nih.gov/pubmed/33129109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100913
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