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Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer

Transthyretin (TTR) is a homotetrameric protein involved in human amyloidosis, including familial amyloid polyneuropathy (FAP). Discovering small-molecule stabilizers of the TTR tetramer is a therapeutic strategy for these diseases. Tafamidis, the only approved drug for FAP treatment, is not effecti...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Cotrina, Ellen Y., Oliveira, Ângela, Leite, José Pedro, Llop, Jordi, Gales, Luis, Quintana, Jordi, Cardoso, Isabel, Arsequell, Gemma
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7583827/
https://ncbi.nlm.nih.gov/pubmed/32998442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197166
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