Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

In familial amyloidotic polyneuropathy, TTR (transthyretin) variants are deposited as amyloid fibrils. It is thought that this process involves TTR tetramer dissociation, which leads to partially unfolded monomers that aggregate and polymerize into amyloid fibrils. This process can be counteracted b...

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Bibliographische Detailangaben
Hauptverfasser: Almeida, Maria Rosário, Macedo, Bárbara, Cardoso, Isabel, Alves, Isabel, Valencia, Gregorio, Arsequell, Gemma, Planas, Antoni, Saraiva, Maria João
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2004
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133839/
https://ncbi.nlm.nih.gov/pubmed/15080795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040011
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