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Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

In familial amyloidotic polyneuropathy, TTR (transthyretin) variants are deposited as amyloid fibrils. It is thought that this process involves TTR tetramer dissociation, which leads to partially unfolded monomers that aggregate and polymerize into amyloid fibrils. This process can be counteracted b...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Almeida, Maria Rosário, Macedo, Bárbara, Cardoso, Isabel, Alves, Isabel, Valencia, Gregorio, Arsequell, Gemma, Planas, Antoni, Saraiva, Maria João
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133839/
https://ncbi.nlm.nih.gov/pubmed/15080795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040011
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