Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

In familial amyloidotic polyneuropathy, TTR (transthyretin) variants are deposited as amyloid fibrils. It is thought that this process involves TTR tetramer dissociation, which leads to partially unfolded monomers that aggregate and polymerize into amyloid fibrils. This process can be counteracted b...

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Hlavní autoři: Almeida, Maria Rosário, Macedo, Bárbara, Cardoso, Isabel, Alves, Isabel, Valencia, Gregorio, Arsequell, Gemma, Planas, Antoni, Saraiva, Maria João
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133839/
https://ncbi.nlm.nih.gov/pubmed/15080795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040011
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