Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer’s Disease Drug Discovery

[Image: see text] Transthyretin (TTR) modulates the deposition, processing, and toxicity of Abeta (Aβ) peptides. We have shown that this effect is enhanced in mice by treatment with small molecules such as iododiflunisal (IDIF, 4), a good TTR stabilizer. Here, we describe the thermodynamics of the f...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Cotrina, Ellen Y., Gimeno, Ana, Llop, Jordi, Jiménez-Barbero, Jesús, Quintana, Jordi, Valencia, Gregorio, Cardoso, Isabel, Prohens, Rafel, Arsequell, Gemma
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115756/
https://ncbi.nlm.nih.gov/pubmed/32124607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01970
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