Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

It is well settled that the amyloidogenic properties of the plasma protein transporter transthyretin (TTR) can be modulated by compounds that stabilize its native tetrameric conformation. TTR is also present in cerebrospinal fluid where it can bind to Aβ-peptides and prevent Aβ aggregation. We have...

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Publicado en:Sci Rep
Main Authors: Rios, Xabier, Gómez-Vallejo, Vanessa, Martín, Abraham, Cossío, Unai, Morcillo, Miguel Ángel, Alemi, Mobina, Cardoso, Isabel, Quintana, Jordi, Jiménez-Barbero, Jesús, Cotrina, Ellen Y., Valencia, Gregorio, Arsequell, Gemma, Llop, Jordi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754432/
https://ncbi.nlm.nih.gov/pubmed/31541162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50071-w
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