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Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone
The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites,...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7578061/ https://ncbi.nlm.nih.gov/pubmed/33087770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74808-0 |
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