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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium m...

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Detalhes bibliográficos
Publicado no:Chem Rev
Main Authors: Zielonka, Jacek, Sikora, Adam, Hardy, Micael, Ouari, Olivier, Vasquez-Vivar, Jeannette, Cheng, Gang, Lopez, Marcos, Kalyanaraman, Balaraman
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611849/
https://ncbi.nlm.nih.gov/pubmed/28654243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.7b00042
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