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Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications

Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases. Currently, the most effective way to deliver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltriphenylphosphonium m...

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Podrobná bibliografie
Vydáno v:Chem Rev
Hlavní autoři: Zielonka, Jacek, Sikora, Adam, Hardy, Micael, Ouari, Olivier, Vasquez-Vivar, Jeannette, Cheng, Gang, Lopez, Marcos, Kalyanaraman, Balaraman
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611849/
https://ncbi.nlm.nih.gov/pubmed/28654243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.7b00042
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