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Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis
Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7(+/−) and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7(+/−) and wild-t...
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| Publicado no: | Mol Psychiatry |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7577905/ https://ncbi.nlm.nih.gov/pubmed/32504050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0801-x |
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