Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Cariprazine (CAR) is a strong inhibitor of the Dhcr7 enzyme, the last enzyme in the cholesterol biosynthesis pathway. We assessed the effects of CAR on maternally exposed Dhcr7(+/−) and wild-type mouse offspring, and tested the biochemical effects of CAR in human serum samples. Dhcr7(+/−) and wild-t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Psychiatry
Prif Awduron: Genaro-Mattos, Thiago C., Anderson, Allison, Allen, Luke B., Tallman, Keri A., Porter, Ned A., Korade, Zeljka, Mirnics, Károly
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Immediate Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577905/
https://ncbi.nlm.nih.gov/pubmed/32504050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0801-x
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