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Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness

BACKGROUND: How, and the extent to which, evolution acts on DNA and protein sequences to ensure mutational robustness and evolvability is a long-standing open question in the field of molecular evolution. We addressed this issue through the first structurome-scale computational investigation, in whi...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Schwersensky, Martin, Rooman, Marianne, Pucci, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576759/
https://ncbi.nlm.nih.gov/pubmed/33081759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00870-9
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