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Codon usage determines the mutational robustness, evolutionary capacity and virulence of an RNA virus
RNA viruses exist as dynamic and diverse populations shaped by constant mutation and selection. Yet little is known about how the mutant spectrum contributes to virus evolvability and pathogenesis. Because several codon choices are available for a given amino acid, a central question concerns whethe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504468/ https://ncbi.nlm.nih.gov/pubmed/23159052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.10.008 |
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