Autophagy‐Sirt3 axis decelerates hematopoietic aging

Autophagy suppresses mitochondrial metabolism to preserve hematopoietic stem cells (HSCs) in mice. However, the mechanism by which autophagy regulates hematopoietic aging, in particular in humans, has largely been unexplored. Here, we demonstrate that reduction of autophagy in both hematopoietic cel...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Fang, Yixuan, An, Ni, Zhu, Lingjiang, Gu, Yue, Qian, Jiawei, Jiang, Gaoyue, Zhao, Ruijin, Wei, Wen, Xu, Li, Zhang, Gaochuan, Yao, Xingyun, Yuan, Na, Zhang, Suping, Zhao, Yun, Wang, Jianrong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576273/
https://ncbi.nlm.nih.gov/pubmed/32951306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13232
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