Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models

Transforming growth factor beta-1 (TGFβ1) is a major driver of vascular smooth muscle cell (VSMC) phenotypic switching, an important pathobiology in arterial disease. We performed RNA-sequencing of TGFβ1-stimulated human aortic or arterial VSMCs which revealed large and consistent upregulation of In...

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Pubblicato in:Sci Rep
Autori principali: Lim, Wei-Wen, Corden, Ben, Ng, Benjamin, Vanezis, Konstantinos, D’Agostino, Giuseppe, Widjaja, Anissa A., Song, Wei-Hua, Xie, Chen, Su, Liping, Kwek, Xiu-Yi, Tee, Nicole G. Z., Dong, Jinrui, Ko, Nicole S. J., Wang, Mao, Pua, Chee Jian, Jamal, Muhammad H., Soh, Beeyong, Viswanathan, Sivakumar, Schafer, Sebastian, Cook, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576123/
https://ncbi.nlm.nih.gov/pubmed/33082445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74944-7
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