Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952089/
https://ncbi.nlm.nih.gov/pubmed/31917819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227505
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