Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952089/
https://ncbi.nlm.nih.gov/pubmed/31917819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227505
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