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Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

Loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and incompletely penetrant craniosynostosis. The impact of LOF in IL11 has not been characterized. We generated IL11 knockout (Il11(−/−)) mice that are born in expected ratios and have normal he...

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書目詳細資料
發表在:Sci Rep
Main Authors: Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266813/
https://ncbi.nlm.nih.gov/pubmed/34239012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93623-9
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