Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

Loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and incompletely penetrant craniosynostosis. The impact of LOF in IL11 has not been characterized. We generated IL11 knockout (Il11(−/−)) mice that are born in expected ratios and have normal he...

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Pubblicato in:Sci Rep
Autori principali: Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266813/
https://ncbi.nlm.nih.gov/pubmed/34239012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93623-9
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