Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

IL11 is important for fibrosis in non-alcoholic steatohepatitis (NASH) but its role beyond the stroma in liver disease is unclear. Here, we investigate the role of IL11 in hepatocyte lipotoxicity. Hepatocytes highly express IL11RA and secrete IL11 in response to lipid loading. Autocrine IL11 activit...

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Publicado no:Nat Commun
Main Authors: Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K., Chothani, Sonia P., Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole S. J., Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782504/
https://ncbi.nlm.nih.gov/pubmed/33397952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20303-z
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