Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-specific, conditional expression of murine IL11 in a...

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Veröffentlicht in:PLoS One
Hauptverfasser: Lim, Wei-Wen, Ng, Benjamin, Widjaja, Anissa, Xie, Chen, Su, Liping, Ko, Nicole, Lim, Sze-Yun, Kwek, Xiu-Yi, Lim, Stella, Cook, Stuart Alexander, Schafer, Sebastian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952089/
https://ncbi.nlm.nih.gov/pubmed/31917819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227505
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