Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging

We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables controlled unidirectional flow of media at physiolog...

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Veröffentlicht in:Front Bioeng Biotechnol
Hauptverfasser: Salman, Mootaz M., Marsh, Graham, Kusters, Ilja, Delincé, Matthieu, Di Caprio, Giuseppe, Upadhyayula, Srigokul, de Nola, Giovanni, Hunt, Ronan, Ohashi, Kazuka G., Gray, Taylor, Shimizu, Fumitaka, Sano, Yasuteru, Kanda, Takashi, Obermeier, Birgit, Kirchhausen, Tom
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Bioengineering and Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7576009/
https://ncbi.nlm.nih.gov/pubmed/33117784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.573775
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