A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

BACKGROUND: Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. The aim of this study was to develop a novel model of the human blood–brain barrier (BBB) in a high-throughput microfluidic device. This model can be used to assess passage of l...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Fluids Barriers CNS
Autori principali: Wevers, Nienke R., Kasi, Dhanesh G., Gray, Taylor, Wilschut, Karlijn J., Smith, Benjamin, van Vught, Remko, Shimizu, Fumitaka, Sano, Yasuteru, Kanda, Takashi, Marsh, Graham, Trietsch, Sebastiaan J., Vulto, Paul, Lanz, Henriëtte L., Obermeier, Birgit
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117964/
https://ncbi.nlm.nih.gov/pubmed/30165870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-018-0108-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi