Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet the underlying mechanisms are poorly understoo...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Jung, Seung-Hwan, Lee, Wonseok, Park, Seung-Hyun, Lee, Kang-Yo, Choi, You-Jin, Choi, Soohee, Kang, Dongmin, Kim, Sinri, Chang, Tong-Shin, Hong, Soon-Sun, Lee, Byung-Hoon
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575798/
https://ncbi.nlm.nih.gov/pubmed/33080439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101751
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