Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Mauthe, Mario, Orhon, Idil, Rocchi, Cecilia, Zhou, Xingdong, Luhr, Morten, Hijlkema, Kerst-Jan, Coppes, Robert P., Engedal, Nikolai, Mari, Muriel, Reggiori, Fulvio
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103682/
https://ncbi.nlm.nih.gov/pubmed/29940786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1474314
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