Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial...

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Pubblicato in:Autophagy
Autori principali: Mauthe, Mario, Orhon, Idil, Rocchi, Cecilia, Zhou, Xingdong, Luhr, Morten, Hijlkema, Kerst-Jan, Coppes, Robert P., Engedal, Nikolai, Mari, Muriel, Reggiori, Fulvio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103682/
https://ncbi.nlm.nih.gov/pubmed/29940786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1474314
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