Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet the underlying mechanisms are poorly understoo...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Jung, Seung-Hwan, Lee, Wonseok, Park, Seung-Hyun, Lee, Kang-Yo, Choi, You-Jin, Choi, Soohee, Kang, Dongmin, Kim, Sinri, Chang, Tong-Shin, Hong, Soon-Sun, Lee, Byung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575798/
https://ncbi.nlm.nih.gov/pubmed/33080439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101751
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