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The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer

The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited predisposition to develop different cancers. Due to its im...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Open Biol
Hauptverfasser: Minervini, Giovanni, Pennuto, Maria, Tosatto, Silvio C. E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574549/
https://ncbi.nlm.nih.gov/pubmed/32603638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.200109
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