High throughput single-cell detection of multiplex CRISPR-edited gene modifications

CRISPR-Cas9 gene editing has transformed our ability to rapidly interrogate the functional impact of somatic mutations in human cancers. Droplet-based technology enables the analysis of Cas9-introduced gene edits in thousands of single cells. Using this technology, we analyze Ba/F3 cells engineered...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: ten Hacken, Elisa, Clement, Kendell, Li, Shuqiang, Hernández-Sánchez, María, Redd, Robert, Wang, Shu, Ruff, David, Gruber, Michaela, Baranowski, Kaitlyn, Jacob, Jose, Flynn, James, Jones, Keith W., Neuberg, Donna, Livak, Kenneth J., Pinello, Luca, Wu, Catherine J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574538/
https://ncbi.nlm.nih.gov/pubmed/33081820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02174-1
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