Upregulation of μ-Opioid Receptor in the Rat Spinal Cord Contributes to the α2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain

BACKGROUND: Sustained morphine treatment for cancer pain has been limited due to analgesic tolerance. Opioid receptor internalization and desensitization mediated by downregulation of mu-opioid receptor (MOR) expression have been confirmed as one of the mechanisms of chronic morphine tolerance. In a...

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Detalhes bibliográficos
Publicado no:J Pain Res
Main Authors: Zhang, Pinyi, Bu, Jianlong, Wu, Xiaohong, Deng, Lin, Chi, Meng, Ma, Chao, Shi, Xiaoding, Wang, Guonian
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573317/
https://ncbi.nlm.nih.gov/pubmed/33116804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S274225
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