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HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21
Tripartite motif–containing protein 21 (TRIM21) is a cytosolic antibody receptor that targets the internalized virus–antibody complex to the proteasome for degradation. However, the precise mechanism regulating TRIM21 activity is unknown. Here we show that TRIM21 is a substrate of histone deacetylas...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573261/ https://ncbi.nlm.nih.gov/pubmed/32796032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011006 |
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