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Critical Residue Properties for Potency and Selectivity of α-Conotoxin RgIA Towards α9α10 Nicotinic Acetylcholine Receptors

The α9α10 nicotinic acetylcholine receptor (nAChR) has been characterized as an effective anti-pain target that functions through a non-opioid mechanism. However, as a pentameric ion channel comprised of two different subunits, the specific targeting of α9α10 nAChRs has proven challenging. Previousl...

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Détails bibliographiques
Publié dans:Biochem Pharmacol
Auteurs principaux: Huynh, Peter N., Harvey, Peta J., Gajewiak, Joanna, Craik, David J., Michael McIntosh, J.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572646/
https://ncbi.nlm.nih.gov/pubmed/32593612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114124
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