Inflammasome formation in the lungs of patients with fatal COVID-19

OBJECTIVE: The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2, triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome-mediated release of interleukin-1 family cytokines is important in hyper-inflammatory syndromes, like happens in SARS-CoV-2-mediated cy...

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Détails bibliographiques
Publié dans:Inflamm Res
Auteurs principaux: Toldo, Stefano, Bussani, Rossana, Nuzzi, Vincenzo, Bonaventura, Aldo, Mauro, Adolfo G., Cannatà, Antonio, Pillappa, Raghavendra, Sinagra, Gianfranco, Nana-Sinkam, Patrick, Sime, Patricia, Abbate, Antonio
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2020
Sujets:
Short Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572246/
https://ncbi.nlm.nih.gov/pubmed/33079210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-020-01413-2
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