Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition

PAR (protease-activated receptor)-4 antagonism has antiplatelet effects under conditions of high shear stress. We aimed to establish whether PAR4 antagonism had additive antithrombotic activity in the presence of factor Xa inhibition in an ex vivo model of acute arterial injury. APPROACH AND RESULTS...

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Dades bibliogràfiques
Publicat a:Arterioscler Thromb Vasc Biol
Autors principals: Meah, Mohammed N., Raftis, Jennifer, Wilson, Simon J., Perera, Vidya, Garonzik, Samira M., Murthy, Bindu, Everlof, J. Gerry, Aronson, Ronald, Luettgen, Joseph, Newby, David E.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2020
Matèries:
Translational Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571844/
https://ncbi.nlm.nih.gov/pubmed/32907366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314960
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