Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition

PAR (protease-activated receptor)-4 antagonism has antiplatelet effects under conditions of high shear stress. We aimed to establish whether PAR4 antagonism had additive antithrombotic activity in the presence of factor Xa inhibition in an ex vivo model of acute arterial injury. APPROACH AND RESULTS...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arterioscler Thromb Vasc Biol
Prif Awduron: Meah, Mohammed N., Raftis, Jennifer, Wilson, Simon J., Perera, Vidya, Garonzik, Samira M., Murthy, Bindu, Everlof, J. Gerry, Aronson, Ronald, Luettgen, Joseph, Newby, David E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Lippincott Williams & Wilkins 2020
Pynciau:
Translational Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571844/
https://ncbi.nlm.nih.gov/pubmed/32907366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314960
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