Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition

PAR (protease-activated receptor)-4 antagonism has antiplatelet effects under conditions of high shear stress. We aimed to establish whether PAR4 antagonism had additive antithrombotic activity in the presence of factor Xa inhibition in an ex vivo model of acute arterial injury. APPROACH AND RESULTS...

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Bibliografske podrobnosti
izdano v:Arterioscler Thromb Vasc Biol
Main Authors: Meah, Mohammed N., Raftis, Jennifer, Wilson, Simon J., Perera, Vidya, Garonzik, Samira M., Murthy, Bindu, Everlof, J. Gerry, Aronson, Ronald, Luettgen, Joseph, Newby, David E.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2020
Teme:
Translational Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571844/
https://ncbi.nlm.nih.gov/pubmed/32907366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314960
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