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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
Loss of PTEN, the negative regulator of PI3K activity, is frequent in glioblastomas (GBMs). However, the role of the two major PI3K isoforms, p110α and p110β, in PTEN-deficient gliomagenesis remains unknown. We show that PTEN-deficient GBM largely depends on p110α for proliferation and p110β for mig...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7571617/ https://ncbi.nlm.nih.gov/pubmed/32997991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108196 |
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