PET imaging of distinct brain uptake of a nanobody and similarly-sized PAMAM dendrimers after intra-arterial administration

INTRODUCTION: We have recently shown that intracerebral delivery of an anti-VEGF monoclonal antibody bevacizumab using an intra-arterial (IA) infusion is more effective than intravenous administration. While antibodies are quickly emerging as therapeutics, their disadvantages such as large size, pro...

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Detalhes bibliográficos
Publicado no:Eur J Nucl Med Mol Imaging
Main Authors: Lesniak, Wojciech G, Chu, Chengyan, Jablonska, Anna, Azad, Babak Behnam, Zwaenepoel, Olivier, Zawadzki, Michal, Lisok, Ala, Pomper, Martin, Walczak, Piotr, Gettemans, Jan, Janowski, Miroslaw
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571511/
https://ncbi.nlm.nih.gov/pubmed/31161257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04347-y
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