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Divergent Synthesis of Complex Diterpenes via a Hybrid Oxidative Approach

Polycyclic diterpenes exhibit many important biological activities, but de novo synthetic access to these molecules is highly challenging due to their structural complexity. Semisynthetic access has also been limited by the lack of chemical tools for scaffold modifications. We report a chemoenzymati...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Zhang, Xiao, King-Smith, Emma, Dong, Liao-Bin, Yang, Li-Cheng, Rudolf, Jeffrey D., Shen, Ben, Renata, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569743/
https://ncbi.nlm.nih.gov/pubmed/32792393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abb8271
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