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Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway

Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis. However, the form of these signaling changes is uncertain, with activating RAS mutants linked to both increased and decreased ERK activation in vi...

詳細記述

保存先:
書誌詳細
出版年:Mol Syst Biol
主要な著者: Gillies, Taryn E, Pargett, Michael, Silva, Jillian M, Teragawa, Carolyn K, McCormick, Frank, Albeck, John G
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569415/
https://ncbi.nlm.nih.gov/pubmed/33073539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20209518
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