Systems-level properties of EGFR/RAS/ERK signaling amplify local signals to generate dynamic gene expression heterogeneity

Intratumoral heterogeneity is associated with aggressive tumor behavior, therapy resistance, and poor patient outcomes. Such heterogeneity is thought to be dynamic, shifting over periods of minutes to hours in response to signaling inputs from the tumor microenvironment. However, models of this proc...

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Bibliografski detalji
Izdano u:Cell Syst
Glavni autori: Davies, Alexander E., Pargett, Michael, Siebert, Stefan, Gillies, Taryn E., Choi, Yongin, Tobin, Savannah J., Ram, Abhineet R., Murthy, Vaibhav, Juliano, Celina, Quon, Gerald, Bissell, Mina J., Albeck, John G.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856305/
https://ncbi.nlm.nih.gov/pubmed/32726596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.07.004
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