Linear integration of ERK activity predominates over persistence detection in Fra-1 regulation

ERK signaling regulates the expression of target genes, but it is unclear how ERK activity dynamics are interpreted. Here, we investigate this question using simultaneous, live, single-cell imaging of two ERK activity reporters and expression of Fra-1, a target gene controlling epithelial cell ident...

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Udgivet i:Cell Syst
Main Authors: Gillies, Taryn E., Pargett, Michael, Minguet, Marta, Davies, Alex E., Albeck, John G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746471/
https://ncbi.nlm.nih.gov/pubmed/29199017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.10.019
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