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Linear integration of ERK activity predominates over persistence detection in Fra-1 regulation
ERK signaling regulates the expression of target genes, but it is unclear how ERK activity dynamics are interpreted. Here, we investigate this question using simultaneous, live, single-cell imaging of two ERK activity reporters and expression of Fra-1, a target gene controlling epithelial cell ident...
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| Publicado no: | Cell Syst |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5746471/ https://ncbi.nlm.nih.gov/pubmed/29199017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.10.019 |
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