Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway

The result of our previous study has shown that the K-ras mutant (pK568MRSV) transfected human adrenocortical cells can significantly increase cortisol production and independently cause cell transformation. The aim of this study is to investigate the effect of the active K-ras oncogene on the corti...

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Bibliografiske detaljer
Main Authors: Wu, C-H, Chen, Y-F, Wang, J-Y, Hsieh, M-C, Yeh, C-S, Lian, S-T, Shin, S-J, Lin, S-R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Molecular and Cellular Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364317/
https://ncbi.nlm.nih.gov/pubmed/12434292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600589
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