Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

OBJECTIVE: The HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin. DESIGN: We explored, in relevant cellular models of HBV replication, the functional co...

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Vydáno v:Gut
Hlavní autoři: Salerno, Debora, Chiodo, Letizia, Alfano, Vincenzo, Floriot, Oceane, Cottone, Grazia, Paturel, Alexia, Pallocca, Matteo, Plissonnier, Marie-Laure, Jeddari, Safaa, Belloni, Laura, Zeisel, Mirjam, Levrero, Massimo, Guerrieri, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Hepatology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569396/
https://ncbi.nlm.nih.gov/pubmed/32114505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2019-319637
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