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The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1 diabetes (T1D) but is also recognized by CD8(+) T cells from healthy individuals. We quantified PPI-specific CD8(+) T cells within different areas of the human pancreas from nondiabetic controls, autoantibody...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7567597/ https://ncbi.nlm.nih.gov/pubmed/33067232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5586 |
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