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Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER export

Therapeutic monoclonal antibodies against the PD-L1/PD-1 (programmed death ligand-1/programmed cell death protein-1) axis have achieved great successes in cancer treatments, but the development of small-molecule immunomodulators of the pathway has lagged far behind. We established a cellular cocultu...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Chen, Fang-Fang, Li, Zheng, Ma, Dawei, Yu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567511/
https://ncbi.nlm.nih.gov/pubmed/33110706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1831153
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