NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation

Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H(2)O(2) generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical trials for idiopathic pulmonary fibrosis...

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Publicat a:Redox Biol
Autors principals: Stenke, Emily, Aviello, Gabriella, Singh, Ashish, Martin, Sean, Winter, Des, Sweeney, Brian, McDermott, Michael, Bourke, Billy, Hussey, Seamus, Knaus, Ulla G.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567035/
https://ncbi.nlm.nih.gov/pubmed/33059312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101752
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