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Protocol for the Generation of Human Pluripotent Reporter Cell Lines Using CRISPR/Cas9

Reporter cell lines based on human pluripotent stem cells (hPSCs) are highly desirable for studying differentiation, lineage tracing, and target cell selection. However, several technical bottlenecks, such as DNA transduction, low homology recombination rate (HDR), and single-cell cloning, have made...

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Detalles Bibliográficos
Publicado en:STAR Protoc
Main Authors: Zhong, Aaron, Li, Mu, Zhou, Ting
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566848/
https://ncbi.nlm.nih.gov/pubmed/33073252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2020.100052
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